Bioequivalence and Bioavailability Forum • Degenerated trapezoid ;-)

Degenerated trapezoid ;-) [🇷 for BE/BA]

posted by yjlee168 – Kaohsiung, Taiwan, 2008-12-18 09:44 (6025 d 20:09 ago) – Posting: # 2939
Views: 10,011

dear DLabes,

Weird! I just run bear again and what I get is displayed as follows.

[...]                    Reference                      

---------------------------------------------------



<< NCA Output:- Subject# 1  (Ref.)>>

--------------------------------------------------------------------------

   subj  time   conc  AUC(0-t) AUMC(0-t)

1     1  0.00    0.0     0.000     0.000

2     1  0.25   36.1     4.513     1.128

3     1  0.50  125.0    24.650    10.069

4     1  0.75  567.0   111.150    71.037

5     1  1.00  932.0   298.525   240.694

6     1  1.50 1343.0   867.275   977.319

7     1  2.00 1739.0  1637.775  2350.444

8     1  3.00 1604.0  3309.275  6495.444

9     1  4.00 1460.0  4841.275 11821.444

10    1  8.00  797.0  9355.275 36253.444

11    1 12.00  383.0 11715.275 58197.444

12    1 24.00   72.0 14445.275 96141.444[...]

which is identical to what you got (14445.275]. Could you please update all your R packages (from R console, plz) again? This is because there seems a big change from v2.7.2 to v2.8.0. My desktop PC system is Win/Vista sp1,R v2.8.0 and bear v2.0.1. If you update all packages of R from its console, it will also automatically update all packages that will be called by bear. Sorry about this.

❝ [...]

❝ For that data I have calculated AUC(0-t)=14445.275.

❝ [...]

—
All the best,
-- Yung-jin Lee
bear v2.9.2:- created by Hsin-ya Lee & Yung-jin Lee
Kaohsiung, Taiwan https://www.pkpd168.com/bear
Download link (updated) -> here

Complete thread:

AUC in Bear d_labes 2008-12-15 15:19
- AUC in Bear yjlee168 2008-12-17 18:57
  - Degenerated trapezoid ;-) d_labes 2008-12-18 08:25
    - Degenerated trapezoid ;-)yjlee168 2008-12-18 08:44
      - Bear at Home d_labes 2008-12-18 09:02
        
        Bear at Home yjlee168 2008-12-18 09:47
        
        Bear - statistical summary d_labes 2008-12-18 11:46
        
        Bear - statistical summary yjlee168 2008-12-18 12:13