Bioequivalence and Bioavailability Forum • AUC in Bear

AUC in Bear [🇷 for BE/BA]

posted by yjlee168 – Kaohsiung, Taiwan, 2008-12-17 19:57 (6026 d 14:22 ago) – Posting: # 2935
Views: 10,080

dear SASophylic DLabes,

Yes, the built-in dataset (for demo purpose) was the 'oral' dataset. The time zero was absolutely included. The first piece AUC is not exactly a trapezoid, but a triangle. At the time zero with oral data, the drug concentration is supposed to be 'zero', unless the washout period is not long enough. If there is a missing value due to any reason, bear will treat it as 'zero' concentration. Very sorry about this delayed response.

❝ Any reasons for that, if really not included?

❝ Is this not an 'oral' application dataset?

❝

❝ Further question: What about missing values at t=0.25 h (f.i. subject 2, 4

❝ ...) for the built-in dataset. Missing or <LLOQ?

—
All the best,
-- Yung-jin Lee
bear v2.9.2:- created by Hsin-ya Lee & Yung-jin Lee
Kaohsiung, Taiwan https://www.pkpd168.com/bear
Download link (updated) -> here

Complete thread:

AUC in Bear d_labes 2008-12-15 15:19
- AUC in Bearyjlee168 2008-12-17 18:57
  - Degenerated trapezoid ;-) d_labes 2008-12-18 08:25
    - Degenerated trapezoid ;-) yjlee168 2008-12-18 08:44
      - Bear at Home d_labes 2008-12-18 09:02
        
        Bear at Home yjlee168 2008-12-18 09:47
        
        Bear - statistical summary d_labes 2008-12-18 11:46
        
        Bear - statistical summary yjlee168 2008-12-18 12:13