Bioequivalence and Bioavailability Forum • Imbalance or incomplete data, SASophylistic view

Imbalance or incomplete data, SASophylistic view [🇷 for BE/BA]

posted by yjlee168 – Kaohsiung, Taiwan, 2008-11-07 06:12 (6066 d 20:24 ago) – Posting: # 2640
Views: 33,460

Dear DLabes,

In order to validate bear with your SAS outputs, could you please provide detailed anova output obtained from your SAS runs? Such as that we got anova output obtained from bear with Helmut's data (of balanced seq.) as follow:

Dependent Variable: Cmax 



Type I SS

Analysis of Variance Table



Response: Cmax

          Df Sum Sq Mean Sq F value    Pr(>F)   

seq        1  239.9   239.9  5.1601   0.03324 * 

prd        1   14.2    14.2  0.3053   0.58615   

drug       1    5.3     5.3  0.1133   0.73960   

seq:subj  22 5987.3   272.2  5.8547 5.389e-05 ***

Residuals 22 1022.6    46.5                     

---

Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1



Type III SS

Single term deletions



Model:

Cmax ~ seq + subj:seq + prd + drug

         Df Sum of Sq    RSS    AIC F value     Pr(F)   

<none>                1022.6  198.8                     

prd       1      14.2 1036.8  197.5  0.3053    0.5861   

drug      1       5.3 1027.9  197.1  0.1133    0.7396   

seq:subj 22    5987.3 7010.0  247.2  5.8547 5.389e-05 ***

---

Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1



Tests of Hypothesis for SUBJECT(SEQUENCE) as an error term



Error: subj

          Df Sum Sq Mean Sq F value Pr(>F)

prd:drug   1  239.9   239.9  0.8813  0.358

Residuals 22 5987.3   272.2               



Error: Within

          Df  Sum Sq Mean Sq F value Pr(>F)

prd        1   14.19   14.19  0.3053 0.5861

drug       1    5.27    5.27  0.1133 0.7396

Residuals 22 1022.65   46.48

Thank you.

—
All the best,
-- Yung-jin Lee
bear v2.9.2:- created by Hsin-ya Lee & Yung-jin Lee
Kaohsiung, Taiwan https://www.pkpd168.com/bear
Download link (updated) -> here

Complete thread:

bear v2.0.1 (upwards) cont'd yjlee168 2008-10-26 20:46
- bear v2.0.1 (upwards) cont'd ElMaestro 2008-10-27 20:36
  - bear v2.0.1 (upwards) cont'd yjlee168 2008-10-28 08:59
    - bear v2.0.1 (upwards) cont'd ElMaestro 2008-10-28 09:49
      - Imbalance or incomplete data, SASophylistic view d_labes 2008-10-28 17:14
        
        Imbalance or incomplete data, SASophylistic view yjlee168 2008-10-29 07:36
        
        Incomplete cases d_labes 2008-10-29 09:24
        
        Incomplete cases yjlee168 2008-10-30 07:12
        
        Imbalance or incomplete data, SASophylistic view ElMaestro 2008-10-29 09:27
        
        Gold in discussion d_labes 2008-10-29 09:56
        
        Gold? Helmut 2008-10-29 13:03
        
        Imbalance or incomplete data, WinNonlin5.2.1 Helmut 2008-10-29 12:12
        
        Incomplete data, SAS9.2 d_labes 2008-10-29 16:38
        
        Missing values, imputation; separate study ElMaestro 2008-10-30 08:57
        Incomplete data, SAS9.2, DDF option residual d_labes 2008-10-30 15:54
        
        Never belief in any software you haven't written yourself Helmut 2008-10-30 16:30
        
        Imbalance or incomplete data, SASophylistic viewyjlee168 2008-11-07 05:12
        
        Imbalance or incomplete data, SASophylistic view d_labes 2008-11-11 08:35
        
        Imbalance or incomplete data, SASophylistic view yjlee168 2008-11-11 08:54
        
        Imbalance or incomplete data, SASophylistic view d_labes 2008-11-11 13:13
        
        Imbalance or incomplete data, SASophylistic view yjlee168 2008-11-11 13:35
        
        Imbalance or incomplete data, SASophylistic view d_labes 2008-11-11 14:02
        
        Notification about new posts Helmut 2008-11-11 12:24
        
        Notification about new posts d_labes 2008-11-11 13:24
        
        3 Prerequisites for biostatistics Helmut 2008-11-11 13:39
        
        3 Prerequisites for biostatistics d_labes 2008-11-11 14:09