Bioequivalence and Bioavailability Forum • Missing values, imputation; separate study

Missing values, imputation; separate study [🇷 for BE/BA]

posted by ElMaestro – Denmark, 2008-10-30 09:57 (6445 d 06:09 ago) – Posting: # 2611
Views: 38,990

Hey hey hey,

Having thought a little about this discussion, I almost feel for initiating a dry study investigating some of the issues in this thread. It would be interesting to find out which approach performs better (if an objective measure of that can be defined) when there are missing period data for one or more subjects. In particular it would be great FUN (and of potential interest to the PK oracles at EMEA) to play around with imputation methods and see if it is possible to find an imputation approach that outperforms linear mixed effect models.

Comments?

EM.

Complete thread:

bear v2.0.1 (upwards) cont'd yjlee168 2008-10-26 20:46
- bear v2.0.1 (upwards) cont'd ElMaestro 2008-10-27 20:36
  - bear v2.0.1 (upwards) cont'd yjlee168 2008-10-28 08:59
    - bear v2.0.1 (upwards) cont'd ElMaestro 2008-10-28 09:49
      - Imbalance or incomplete data, SASophylistic view d_labes 2008-10-28 17:14
        
        Imbalance or incomplete data, SASophylistic view yjlee168 2008-10-29 07:36
        
        Incomplete cases d_labes 2008-10-29 09:24
        
        Incomplete cases yjlee168 2008-10-30 07:12
        
        Imbalance or incomplete data, SASophylistic view ElMaestro 2008-10-29 09:27
        
        Gold in discussion d_labes 2008-10-29 09:56
        
        Gold? Helmut 2008-10-29 13:03
        
        Imbalance or incomplete data, WinNonlin5.2.1 Helmut 2008-10-29 12:12
        
        Incomplete data, SAS9.2 d_labes 2008-10-29 16:38
        
        Missing values, imputation; separate studyElMaestro 2008-10-30 08:57
        Incomplete data, SAS9.2, DDF option residual d_labes 2008-10-30 15:54
        
        Never belief in any software you haven't written yourself Helmut 2008-10-30 16:30
        
        Imbalance or incomplete data, SASophylistic view yjlee168 2008-11-07 05:12
        
        Imbalance or incomplete data, SASophylistic view d_labes 2008-11-11 08:35
        
        Imbalance or incomplete data, SASophylistic view yjlee168 2008-11-11 08:54
        
        Imbalance or incomplete data, SASophylistic view d_labes 2008-11-11 13:13
        
        Imbalance or incomplete data, SASophylistic view yjlee168 2008-11-11 13:35
        
        Imbalance or incomplete data, SASophylistic view d_labes 2008-11-11 14:02
        
        Notification about new posts Helmut 2008-11-11 12:24
        
        Notification about new posts d_labes 2008-11-11 13:24
        
        3 Prerequisites for biostatistics Helmut 2008-11-11 13:39
        
        3 Prerequisites for biostatistics d_labes 2008-11-11 14:09