Type III SS in balanced, crossover BE studies? [🇷 for BE/BA]

posted by yjlee168 Homepage – Kaohsiung, Taiwan, 2008-10-18 23:03 (6090 d 03:23 ago) – Posting: # 2557
Views: 71,254

dear EM,

Although now bear v2.0.1 calculates Type III SS with ANOVA, Type III SS are the same as the Type I SS when the BE study is a balanced, crossover design. Bear is now only applicable to a balanced, crossover designed BE study. So, can 'some regulators' agree with this or are they willing to accept Type I SS in this situation? Thanks.

❝ 4. Although Sums-of-Squares is pretty much a mine field, I think it would be wise to at least implement an option of getting type III SS. Some regulators seem unwilling to accept anything other than type III, while others couldn't care less (I have it on good account :-D). This means that the choice of type III is a safe choice for the time being.


All the best,
-- Yung-jin Lee
bear v2.9.2:- created by Hsin-ya Lee & Yung-jin Lee
Kaohsiung, Taiwan https://www.pkpd168.com/bear
Download link (updated) -> here
Thread locked

Complete thread:

UA Flag
Activity
 Admin contact
23,424 posts in 4,927 threads, 1,671 registered users;
54 visitors (0 registered, 54 guests [including 13 identified bots]).
Forum time: 02:27 CEST (Europe/Vienna)

Medical researches can be divided into two sorts:
those who think that meta is better and those
who believe that pooling is fooling.    Stephen Senn

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5