Bioequivalence and Bioavailability Forum • lambda

lambda_z estimation [🇷 for BE/BA]

posted by Aceto81 – Belgium, 2008-09-25 12:56 (6110 d 03:06 ago) – Posting: # 2401
Views: 71,515

❝ I do not own WINNONLIN, but I suggest that the point t_max, C_max should not be included in the terminal part.

❝

❝ I further suggest that the TTT (two-times t_max) rule should be implemented to restrict the number of points in the terminal part, provided that at least 3 points are available.

❝ See this thread for the TTT rule.

❝

❝ May be the Akaike information criterion AIC (especially the AICc, small sample formula) is a better choice than adj. RSquare.

If the C_max may not be included, this explains the difference between the R code and WinNonlin.
If you change
for (i in (nrow(dat)-3):which.max(dat$conc))
to
for (i in (nrow(dat)-3):(which.max(dat$conc)+1))
then C_max is excluded.

And you would get the same result as WinNonlin.

Ace

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Complete thread:

bear v1.0.0 - a data analytical tool for ABE in R yjlee168 2008-07-12 20:53
- bear v1.0.0 for R - first impressions Helmut 2008-07-14 04:12
  - bear v1.0.0 for R - first impressions yjlee168 2008-07-14 10:26
    - bear v1.0.0 for R - first impressions Helmut 2008-07-14 14:02
      - bear v1.0.0 for R - first impressions yjlee168 2008-07-14 18:12
        
        bear v1.0.0 for R... Helmut 2008-07-14 18:56
        
        bear v1.0.0 for R... yjlee168 2008-07-14 19:30
        
        bear v1.0.0 for R... Helmut 2008-07-14 20:35
      - bear v1.0.0 for R - first impressions yjlee168 2008-07-15 09:44
- bear v1.0.0 - a data analytical tool for ABE in R martin 2008-07-14 12:18
  - bear v1.0.0 - a data analytical tool for ABE in R yjlee168 2008-07-14 19:02
    - bear v1.0.0 - a data analytical tool for ABE in R Aceto81 2008-07-15 10:07
      - bear v1.0.0 - a data analytical tool for ABE in R yjlee168 2008-07-16 07:22
        
        bear v1.0.0 - a data analytical tool for ABE in R Aceto81 2008-07-16 09:47
        
        bear v1.0.0 - a data analytical tool for ABE in R yjlee168 2008-07-16 21:32
      - lambda_z estimation yjlee168 2008-09-23 12:13
        
        lambda_z estimation d_labes 2008-09-23 14:41
        
        lambda_z estimation yjlee168 2008-09-24 22:41
        lambda_z estimationAceto81 2008-09-25 10:56
        
        lambda_z estimation yjlee168 2008-09-25 21:00
        lambda_z estimation yjlee168 2008-09-26 08:03
        
        lambda_z estimation Aceto81 2008-09-26 10:25
        
        lambda_z estimation yjlee168 2008-09-28 00:08
        lambda_z estimation yjlee168 2008-09-29 13:32
        
        WinNonlin 5.2.1 vs. 6 beta Helmut 2008-09-29 15:54
        
        WinNonlin 5.2.1 vs. 6 beta yjlee168 2008-09-29 18:45
        WinNonlin 5.2.1 vs. 6 beta --> new finding yjlee168 2008-09-30 08:10
        
        Example 4 in SASophylistic d_labes 2008-09-30 09:43
        
        Example 4 in SASophylistic yjlee168 2008-09-30 12:23
        
        TTT method for lambda_z estimation yjlee168 2008-09-30 12:34
        
        TTT method for lambda_z estimation d_labes 2008-09-30 14:48
        
        TTT method for lambda_z estimation yjlee168 2008-09-30 20:28
        
        TTT method plus best fit combined d_labes 2008-10-01 08:43
        
        AIC or ARS as the best fit criterion? yjlee168 2008-10-02 12:40
        
        AIC or ARS as the best fit criterion? d_labes 2008-10-02 13:59
        
        TTT method for lambda_z estimation Aceto81 2008-09-30 15:11
        
        TTT method for lambda_z estimation yjlee168 2008-09-30 19:57
        
        TTT method for lambda_z estimation Aceto81 2008-10-01 14:18
        
        TTT method for lambda_z estimation yjlee168 2008-10-02 12:29
        
        TTT method for lambda_z estimation Aceto81 2008-10-03 15:33
        
        TTT method for lambda_z estimation yjlee168 2008-10-03 21:22
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  - bear v1.0.0 - a data analytical tool for ABE in R yjlee168 2008-07-23 09:55
    - bear v1.0.0 - a data analytical tool for ABE in R ElMaestro 2008-07-24 10:04
      - bear v1.0.0 - a data analytical tool for ABE in R yjlee168 2008-07-25 20:38
        
        bear v1.0.0 - a data analytical tool for ABE in R ElMaestro 2008-07-28 08:42
    - bear v1.0.0 - a data analytical tool for ABE in R ElMaestro 2008-09-23 16:10
      - bear v1.0.0 - a data analytical tool for ABE in R yjlee168 2008-09-24 22:00
        
        bear v1.0.0 - a data analytical tool for ABE in R ElMaestro 2008-09-25 09:03
        
        bear v1.0.0 - a data analytical tool for ABE in R ElMaestro 2008-09-25 13:52
        
        bear v1.0.0 - a data analytical tool for ABE in R Helmut 2008-09-25 14:39
        
        bear v1.0.0 - a data analytical tool for ABE in R ElMaestro 2008-09-25 14:55
        
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        lm in R ElMaestro 2008-09-26 09:15
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  - Type III SS in balanced, crossover BE studies? yjlee168 2008-10-18 21:03
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        Thread locked Helmut 2008-10-24 11:58