Bioequivalence and Bioavailability Forum • Time above MIC (WinNonlin 5.2.1)

Time above MIC (WinNonlin 5.2.1) [🇷 for BE/BA]

posted by Aceto81 – Belgium, 2008-08-12 11:56 (6156 d 13:49 ago) – Posting: # 2169
Views: 37,194

Wow Helmut,

you did a hell of a job.
Great thinking!

Do you think that the log/linear approach for the descending part is better than the classic linear approach?
As you already stated, the elimination phase is log/linear, so maybe this is more correct than the 'classic' approach.

Or maybe we can choose, as long as we clearly report which method we used?

Best regards

Ace
PS: anyone interested in the full R code with an extension to choose log or not?

Complete thread:

Calculation of time above MIC Aceto81 2008-06-26 16:31
- Calculation of time above MIC Helmut 2008-06-26 18:58
  - Calculation of time above MIC Aceto81 2008-06-26 21:50
    - Calculation of time above MIC Helmut 2008-06-27 00:18
    - Calculation of time above MIC Helmut 2008-06-29 02:24
      - Calculation of time above MIC Aceto81 2008-06-30 15:50
        
        Therapeutic Occupancy Time / MEC Helmut 2008-06-30 16:45
  - Time above MIC (WinNonlin 5.2.1) Helmut 2008-08-08 20:38
    - Time above MIC (WinNonlin 5.2.1)Aceto81 2008-08-12 09:56
      - Time above MIC (WinNonlin 5.2.1) Helmut 2008-08-12 12:32
        
        Time above MIC (R function) Aceto81 2008-08-13 11:19
        
        Time above MIC (R function) Helmut 2008-08-13 13:18
        
        Time above MIC (R function) Aceto81 2008-08-13 15:35
        
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