Bioequivalence and Bioavailability Forum

Automatic → visual inspection/adjustment [🇷 for BE/BA]

posted by yjlee168  – Kaohsiung, Taiwan, 2019-11-20 19:48 (2038 d 19:07 ago) – Posting: # 20845
Views: 8,345

Dear Helmut,

❝ Why not? I do that for decades and never got a question from any agency.

I see. for decades?

❝ — Any [sic] automatic algo performs badly for “flat” profiles (e.g., modified release) and terrible for multiphasic products.

Right. It is indeed quite possible for some modified releases. It makes sense.

❝ — Visual inspection / adjustment recommended in the literature.

❝ — Stated not only in my SOP but also in the protocol: Automatic method first (I’m lazy and in most cases it works), adjustment second.

Smart strategy. Thanks for your messages. I learned.

Complete thread:

• Previously data point selection for lambda z estimate issue in bear kvoronov 2019-11-20 10:55 
  • Previously data point selection for lambda z estimate issue in bear yjlee168 2019-11-20 14:07
    • Previously data point selection for lambda z estimate issue in bear kvoronov 2019-11-20 15:40
      • combine ARS & manual selection for lambda z in bear yjlee168 2019-11-20 17:12
        • Automatic → visual inspection/adjustment Helmut 2019-11-20 17:32
          • Automatic → visual inspection/adjustmentyjlee168 2019-11-20 18:48
            • Automatic → visual inspection/adjustment Helmut 2019-11-20 18:59
              • Automatic → visual inspection/adjustment yjlee168 2019-11-20 21:05
                • OT for nerds Helmut 2019-11-21 00:53
        • combine ARS & manual selection for lambda z in bear kvoronov 2019-11-21 21:57
          • combine ARS & manual selection for lambda z in bear yjlee168 2019-11-21 22:15
            • combine ARS & manual selection for lambda z in bear kvoronov 2019-11-22 13:57
              • bear v2.8.7 is released. yjlee168 2019-11-22 20:48
                • bear v2.8.7 is released. kvoronov 2019-11-25 18:14
                  • auto switch from ARS to manual selection yjlee168 2019-11-25 20:46
                    • auto switch from ARS to manual selection kvoronov 2019-11-28 14:19