Bioequivalence and Bioavailability Forum • PE vs GMR

PE vs GMR [🇷 for BE/BA]

posted by Ohlbe – France, 2018-12-11 01:28 (2383 d 04:43 ago) – Posting: # 19676
Views: 15,881

Dear roman_max,

❝ My question is: does PE and GMR represent different metrics, numerically and/or statistically?

Yes.

❝ On the one hand GMR by definition is a ratio of LSM T/LSM R

No. This is PE. The GMR is the ratio of geometric means, not of LSM (LSMEAN in SAS-speak). For more details on how to calculate LSM and the difference between LSM and geometric mean, see this oldie.

PE and GMR will be identical if you have a balanced study (same number of subjects in sequence RT and sequence TR). If the study is unbalanced (e.g. if you have a dropout), you'll get different results. The difference is usually minimal, but can be more important if you have an outlier.

—
Regards
Ohlbe

Complete thread:

PE vs GMR roman_max 2018-12-10 17:53
- PE vs GMROhlbe 2018-12-11 00:28
  - PE vs GMR roman_max 2018-12-12 16:31
    - PE vs GMR in Bear mittyri 2018-12-12 17:40
      - estimate(test-ref) in bear yjlee168 2018-12-12 18:58
        
        estimate(test-ref) and lsmeans in bear mittyri 2018-12-12 22:57
        
        estimate(test-ref) and lsmeans in bear yjlee168 2018-12-13 12:20
- PE vs GMR mittyri 2018-12-11 16:30
  - PE vs GMR roman_max 2018-12-12 16:41
- PE vs GMR ElMaestro 2018-12-12 21:39
  - PE vs GMR roman_max 2018-12-13 23:11
    - SPSS vs lm mittyri 2018-12-14 15:35
      - SPSS vs lm roman_max 2018-12-15 13:37
        
        SPSS BE code mittyri 2018-12-15 22:07
    - PE vs GMR ElMaestro 2018-12-14 16:11