Bioequivalence and Bioavailability Forum

Hi CECIF,

❝ I have been using bear for bioequivalence calculation since version 6.2.

uhh... since version 6.2? bear? the current version is 2.8.3 (as shown in my signature panel).

❝ ... on exception of some of the AUC0inf and AUC0t mostly on the last sampling times which came out a little higher in my calculations (I can only suposse it is because of the decimal numbers).

What was your selection for trapezoidal method? linear-up/log-down (default method) or all linear? That could make a little differences.

❝ ... I have been trying different equations to get it, but I failed in every one.

❝ is it Vd/F= D*Ka/(I(Ka-Ke))? with ka from the residuals method or the wagner-nelson method?

❝ or is it simply Vd/F=D/(AUC0inf*Ke)?

Simply Vd/F=D/(AUC0inf*Ke). Again please check your selected trapezoidal method. It also affects Vd/F too as you can see. What about Cl/F?

Hope this message can help.