Bioequivalence and Bioavailability Forum

Dear D. Labes and YJ Lee,

could you please, advise us about the subject # in the rl.gui in bear2.8.2; why the subject number increase only by 2 in the TRR,RRT,RTR (2x3x3) study design?
I think it should increase by three to give a balanced design? as the following output shows:

"Summary of randomisation

40 subjects randomized into 3 sequence groups.
Number of subjects in sequence groups:
RRT RTR TRR
14 12 14
Runs test of randomness: p.value=0.1798
based on: D. Labes (2017). randomizeBE: Create a Random List for Crossover Studies. R package version 0.3-3. https://CRAN.R-project.org/package=randomizeBE "

Greetings.