Bioequivalence and Bioavailability Forum • lin-up/log-down is bear’s default

lin-up/log-down is bear’s default [🇷 for BE/BA]

posted by Astea – Russia, 2017-05-22 04:12 (3318 d 07:55 ago) – Posting: # 17385
Views: 10,072

Dear Helmut!

Please check the data you've posted in the column "lin/log". Accidently you've summed a previous to the "down" number instead: pay attention, every "no" follows the moment previous to that of falling the concentration (like 22.210 to 18.013). The data in the "bear" column is correct. It also coincides with that of the "linear up log down" method in WinNonLin (1435.6823). For "linear trapezoidal linear interpolation" I've got 1478.6813 in WinNonLin and 1478.7 in bear.

—
"Being in minority, even a minority of one, did not make you mad"

Complete thread:

AUC calculation in bear pjs 2017-05-21 15:57
- lin-up/log-down is bear’s default Helmut 2017-05-21 17:32
  - lin-up/log-down any regulatory recommendation? pjs 2017-05-21 19:08
    - lin-up/log-down any regulatory recommendation? Helmut 2017-05-21 19:14
      - lin-up/log-down any regulatory recommendation? pjs 2017-05-21 19:33
  - lin-up/log-down is bear’s default yjlee168 2017-05-21 20:08
    - lin-up/log-down is bear’s default Yura 2017-05-25 12:52
      - zero (0), missing (NA), or BLLOQ (0 or NA) in bear (II) yjlee168 2017-05-25 14:38
        
        zero (0), missing (NA), or BLLOQ (0 or NA) in bear (II) Yura 2017-05-25 15:17
  - lin-up/log-down is bear’s defaultAstea 2017-05-22 02:12
    - Never use Excel Helmut 2017-05-22 13:19