Bioequivalence and Bioavailability Forum • Getting variance components from the lmer output

Getting variance components from the lmer output [🇷 for BE/BA]

posted by StatR – Turkey, 2017-02-03 18:12 (3059 d 09:41 ago) – Posting: # 17011
Views: 19,693

❝ Yijk seems to be a PK paramenter of interest... Residual you've extracted seems to be pooled both formulations.

Dear VStur,

Thanks for your reply. You are right, Yijk is PK characteristic of interest. The design is 2 sequence 2 treatment and 4 period design(TRTR/RTRT). More clearly, I want to extract between subject variances (sigmaBT^2, sigmaBR^2), within subject variances (sigmaWT^2, sigmaWR^2) under the test and reference formulation, also subject-by-formulation interaction (sigmaD^2 = sigmaBT^2 + sigmaBR^2 - 2*rho*sigmaBT*sigmaBR). Is it possible to obtain all of these estimates from the summary(lmer_model), or do I need to do an extra step to obtain those values?

Thanks in advance

Edit: Full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer; see also this post #5! [Helmut]

Complete thread:

Bear vs. Phoenix & SAS Helmut 2015-04-20 17:34
- R vs. Phoenix & SAS? yjlee168 2015-04-20 19:36
  - R vs. Phoenix & SAS? Helmut 2015-04-21 01:02
    - lme() does not work with all fixed effects yjlee168 2015-04-21 23:41
      - lme() does not work with all fixed effects Astea 2016-11-04 00:13
        
        lmer: Method B (PE catched for imbalanced dataset!!!) and Method C mittyri 2016-11-05 17:38
        
        lmer: Method B (PE catched for imbalanced dataset!!!) and Method C Astea 2016-11-05 19:27
        
        lmer: Method B is ready for scaling mittyri 2016-11-05 20:01
        
        lmer: Method B is ready for scaling Astea 2016-11-06 11:50
        
        lmer: Method B is ready for scaling mittyri 2016-11-07 06:07
- info for lsmeans yjlee168 2015-04-20 21:34
  - info for lsmeans Helmut 2015-04-21 01:15
    - once more about R and replicate designes Astea 2016-11-02 23:43
      - once more about R and replicate designes VStus 2016-11-06 11:34
        
        Getting variance components from the lmer output StatR 2017-02-03 13:53
        
        Getting variance components from the lmer output VStus 2017-02-03 15:47
        
        Getting variance components from the lmer outputStatR 2017-02-03 17:12
        
        Getting variance components d_labes 2017-02-07 11:16
        
        Getting variance components StatR 2017-02-07 11:36
        Getting variance components StatR 2017-02-08 08:41
        
        Getting variance components d_labes 2017-02-08 10:13
        
        Getting variance components StatR 2017-02-08 10:19
        
        Data structure Helmut 2017-02-08 10:33
        
        Data structure StatR 2017-02-08 10:49