Bioequivalence and Bioavailability Forum • old bear and friends

old bear and friends [🇷 for BE/BA]

posted by yjlee168 – Kaohsiung, Taiwan, 2016-09-16 11:42 (3566 d 04:14 ago) – Posting: # 16647
Views: 17,017
(edited on 2016-09-16 18:00)

Dear xtianbadillo,

I wonder that you are using the previous version of bear. I have already fixed the error since v2.7.1. Now it's v2.7.7.

The error comes from that the data point selection method (such as ARS) fails to select at least three data points after C_max to estimate λz. Thus, there is no drug plasma conc. (i.e., 'y') selected at all. That's what the error messages tell us. In other words, you may have at least one subject who had insufficient data points (≧ 3 data points after C_max) to estimate λz. May I know what version of bear you used? You can upgrade bear from Sourceforge if you like (not on CRAN any more; very sorry about that). And try it again with the same dataset using ARS or others. It will tell you which subjects get involved with insufficient data points.

Hope this can help.

❝ ...I changed the default settings as you said and the issue was solved.

—
All the best,
-- Yung-jin Lee
bear v2.9.6:- created by Hsin-ya Lee & Yung-jin Lee
Kaohsiung, Taiwan https://www.pkpd168.com/bear
Download link (updated) -> here

Complete thread:

Difficulties with NCA BEAR PK_Lover 2014-11-21 00:28
- Difficulties with NCA BEAR yjlee168 2014-11-21 07:34
  - Difficulties with NCA BEAR PK_Lover 2014-11-22 00:07
    - Difficulties with NCA BEAR yjlee168 2014-11-22 03:21
      - Difficulties with NCA BEAR PK_Lover 2014-11-22 09:47
        
        help test NCA BEAR yjlee168 2014-12-01 08:13
        
        help test NCA BEAR Emrah Soner Özdeş 2015-01-15 14:37
        
        help test NCA BEAR Jam 2015-01-23 08:55
        
        CSV files with a comma at the end of each line? yjlee168 2015-01-25 04:35
      - Difficulties with NCA BEAR xtianbadillo 2016-09-15 22:44
        
        old bear and friendsyjlee168 2016-09-16 09:42
        
        old bear and friends VStus 2016-09-26 13:30
        
        multiple-dosed study with bear yjlee168 2016-09-26 18:04
        
        multiple-dosed study with bear VStus 2016-10-11 09:01
        
        multiple-dosed study with bear yjlee168 2016-10-11 10:15
        
        multiple-dosed study with bear VStus 2016-10-11 10:37
        multiple-dosed study with bear VStus 2016-10-12 10:37
        
        multiple-dosed study with bear [solved] yjlee168 2016-10-12 18:42