Bioequivalence and Bioavailability Forum • ke versus t1/2

ke versus t1/2 [🇷 for BE/BA]

posted by d_labes – Berlin, Germany, 2016-07-20 18:05 (3257 d 13:18 ago) – Posting: # 16501
Views: 10,774

Dear Helmut,

❝ BTW, asking for a comparison of both k and t_½ demonstrates a lack of understanding of statistics. They differ only by a factor of ln(2). Any comparison will give identical variance, CI, etc.

I think here you err.
t_½ = ln(2)/k (some sort of 'inverse transformation').

Lets consider for simplicity the GMR's (I consider the metric names are the geometric means here):
t_½T/t_½R = (ln(2)/k_T)/(ln(2)/k_R) = k_R/k_T
That's not identical to the GMR for k IMHO :no:

.

BTW: @Mahmoud.
k or k_e will be better called lambda_Z - terminal rate constant.

❝ ❝ 1st order elimination rate constant

is only correct within an one-compartment model.

—
Regards,

Detlew

Complete thread:

ANOVA for lambdaz, half life and tmax in bear 2.7.7 mahmoud-teaima 2016-07-20 11:03
- Egypt: Strange requirements Helmut 2016-07-20 12:25
  - Egypt: Strange requirements mahmoud-teaima 2016-07-20 14:12
    - Output is not from Phoenix/Winnonlin mittyri 2016-07-20 17:00
  - ke versus t1/2d_labes 2016-07-20 16:05
    - ke versus t1/2 Helmut 2016-07-20 16:31
      - ke versus t1/2 d_labes 2016-07-21 14:42
        
        “double“ testing Helmut 2016-07-21 14:54
- tmax in bear 2.7.7 yjlee168 2016-07-20 21:10
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    - tmax in bear 2.7.7 yjlee168 2016-07-21 11:11
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