Bioequivalence and Bioavailability Forum

Merciless peer reviewers [🇷 for BE/BA]

posted by d_labes  – Berlin, Germany, 2016-03-08 09:50 (3391 d 12:11 ago) – Posting: # 16074
Views: 11,115
(edited on 2016-03-08 10:23)

Hi All,

❝ I noticed that at certain combinations PowerTOST would produce errors. e.g., with the following values

❝ sampleN.scABEL(alpha = 0.05, targetpower = 0.8, theta0 = 0.91,


❝                     CV = 0.1, design = "2x2x4", regulator = "EMA")

❝

❝ would produce error

❝ Error in if (pwr <= targetpower) cat(n, " ", formatC(pwr, digits = pd,  :


❝   missing value where TRUE/FALSE needed

Confirmed. My suggestion: Contact the maintainer of that ugly R package and throw the code back in his face .

All jokes aside: Thank you all for bug hunting. The reason identified was a too low starting value n0=2 which leaves no degrees of freedom for the CI. Exactly what Helmut suspected.
Will be corrected in the next version, coming soon. I promise .

BTW: All other scaled ABE sample size functions also suffer from the same potential bug . Shit.

Complete thread:

• PowerTOST sample size EMA full replicate Shuanghe 2016-03-07 18:04 
  • merciless tester! Helmut 2016-03-07 18:56
  • PowerTOST sample size EMA full replicate yjlee168 2016-03-07 20:15
  • Merciless peer reviewersd_labes 2016-03-08 08:50
  • PowerTOST V1.3-4 d_labes 2016-03-09 18:43
  • PowerTOST sample size EMA full replicate Astea 2016-03-24 19:34
    • RSABE is not bijective (lengthy answer) Helmut 2016-03-25 14:23
      • RSABE is not bijective (lengthy answer) Astea 2016-03-27 21:07
        • ABEL sample size examples Helmut 2016-03-28 00:42
          • ABEL sample size: more power! (joke) mittyri 2016-03-28 21:54