Bioequivalence and Bioavailability Forum • PowerTOST sample size FDA full replicate T/R ratio at 85%

PowerTOST sample size FDA full replicate T/R ratio at 85% [🇷 for BE/BA]

posted by d_labes – Berlin, Germany, 2016-01-26 15:07 (3433 d 06:10 ago) – Posting: # 15855
Views: 18,277

Dear Shuanghe,

❝ Many thanks Detlew!

You are welcome.

❝ ❝ This is also the case for your calculations with theta0=0.9, but not so pronounced seen as with theta0=0.85. Check it by power calculations with n=120 for theta0=0.85 or theta0=0.9 and n=32. You will find the minimum (implying max. sample size) below CV=30% in both cases.

❝

❝ Confused by this part. :confused:

What I tried to say here with my Swahili: Your first picture / calculations with T/R ratio 0.9, which you have considered as ok, also has the effects inherent you wondered about with T/R ratio 0.85 but to a lesser not so obvious degree if you look at the sample size.

Count up: post 996

—
Regards,

Detlew

Complete thread:

PowerTOST sample size FDA full replicate T/R ratio at 85% Shuanghe 2016-01-25 17:49
- PowerTOST sample size FDA full replicate T/R ratio at 85% d_labes 2016-01-26 12:05
  - PowerTOST sample size FDA full replicate T/R ratio at 85% Shuanghe 2016-01-26 12:55
    - PowerTOST sample size FDA full replicate T/R ratio at 85%d_labes 2016-01-26 14:07
    - maximum sample size at which CV? Helmut 2016-01-26 16:31
      - maximum sample size at which CV? nobody 2016-01-26 17:40
      - maximum sample size at which CV? d_labes 2016-01-27 08:41
        
        maximum sample size at which CV? nobody 2016-01-27 09:08
        
        OT: Stop - think -act d_labes 2016-01-27 09:31
      - maximum sample size at which CV? Shuanghe 2016-01-28 12:44
        
        target power 90% Helmut 2016-01-28 13:49
        
        PowerTOST update d_labes 2016-02-01 19:16
        
        #1,000 Helmut 2016-02-01 21:49
        
        OT: post #1,000 d_labes 2016-02-02 21:17
        #1,000 ElMaestro 2016-02-03 16:32
        
        #1,000 Helmut 2016-02-03 16:50
        OT: #1,000 d_labes 2016-02-05 15:50
        
        OT: #1,000 ElMaestro 2016-02-05 17:02
        
        OT: #1,000 d_labes 2016-02-05 19:48
        
        OT: #1,000 ElMaestro 2016-02-06 15:45
        
        OT: #1,000 nobody 2016-02-07 09:50