Bioequivalence and Bioavailability Forum

Hello!

I have the data from 2x2x2 crossover trial. The head of file is as needed,

subj,seq,prd,time,conc

After loading the file into R and starting NCA, I get the output:

-> the subj# 40 (Ref.) in sequence# 1, period# 1,
    λz (kel) cannot be calculated with ARS or AIC.
 subj seq prd drug time conc
   40   1   1    1  0.0 0.00
   40   1   1    1  0.5 0.27
   40   1   1    1  1.0 0.36
   40   1   1    1  2.0 0.42
   40   1   1    1  3.0 0.60
   40   1   1    1  4.0 0.70
   40   1   1    1  6.0 0.49

And so on, for many patients... At the end

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What does this mean and what to do with it? Is it something with file (I tried to upload the same data with .RData, .csv, .txt and other formats, all in vane) or bear does not like the data? For sure, my friend performed the analysis in Phoenix and had the result.