Bioequivalence and Bioavailability Forum • insufficient data points for lambda

insufficient data points for lambda_z estimation [🇷 for BE/BA]

posted by yjlee168 – Kaohsiung, Taiwan, 2015-08-27 11:07 (3951 d 13:41 ago) – Posting: # 15351
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Dear BE-proff,

I may know this error. It means that you do not have enough data points to perform linear regression to obtain the terminal elimination rate constant (k_e or lambda_z). I will suggest that you check your dataset carefully and delete the suspected subjects (all periods) with insufficient data points (esp. the one with many NA after Tmax). Alternately, you can choose "manual selection" for lambda_z estimation. It will provide you more clear information about the data quality of each subject. BTW, this error occurs before doing NCA.

—
All the best,
-- Yung-jin Lee
bear v2.9.6:- created by Hsin-ya Lee & Yung-jin Lee
Kaohsiung, Taiwan https://www.pkpd168.com/bear
Download link (updated) -> here

Complete thread:

Error of Bear BE-proff 2015-08-26 11:56
- please give more info for error yjlee168 2015-08-26 12:10
  - please give more info for error BE-proff 2015-08-26 12:38
    - cannot reproduce the error yjlee168 2015-08-26 18:02
      - cannot reproduce the error BE-proff 2015-08-27 08:44
        
        insufficient data points for lambda_z estimationyjlee168 2015-08-27 09:07
        cannot reproduce the error d_labes 2015-08-27 09:22