Bioequivalence and Bioavailability Forum

Dear, mittyri. Thank you. You right, because for subjects 18 and 19 there is no data for Cmax. For example in one period Cmax=0, so we have 20 parts time from 0 to 12 (0,0.25.....12) and Cmax=0. I read hear http://pkpd.kmu.edu.tw/bear/
When a drug plasma/serum/blood concentration is near the end of sampling time and is below LLOQ, this value (entire row) can be deleted if the IndivDP_output function will not be used; The recommended way is to input these data values as 'NA' since bear will handle it properly. However, the first data point at (time = 0, Cp = 0) must be included;
So that why i deleted this rows and noted as NA


What do you recommend me? Indeed these results were processed by another man, i just try repeat his result, but, let's initially view just only one subject, lets' #2
and try process it, after we can see these parameters

In report, for 2 subject another results
1 1 1 Auc0T=7347
1 sequence 1 period and reference drug.
After my analysis
1 sequence 1 period and reference drug AucoT=7244
for another periods the results from that man and my are different too
here the data
http://rghost.ru/6jxsT9y7c

what about 18 and 19, as i right understood these data were excluded from analysis.

So i have design 2x2x4! But how correct process it.
For 2 subject after process, R writes
---------------------------------------------------------------------------
1. xxx_nca_pk.txt:
--> Cmax, Tmax, AUC0t, AUC0inf, AUC0t/AUC0inf, ln(Cmax), ln(AUC0t),
ln(AUC0inf), MRT0inf, T1/2(z), Vd/F, lambda_z, and Cl/F
--> PK parameter summary (NCA outputs)

2. xxx_conc_time_plots.pdf: individual linear and semilog plots,
spaghetti plots, and mean conc. plots.

3. xxx_stat_sum.txt
****************************************************************************
Error in SeqLeg[[2]] : subscript out of bounds


did i correct change 0 for Cmax on NA?