Bioequivalence and Bioavailability Forum • ANOVA F-test results and regulators

ANOVA F-test results and regulators [🇷 for BE/BA]

posted by ElMaestro – Denmark, 2015-06-12 17:29 (4021 d 12:32 ago) – Posting: # 14951
Views: 17,151

Hmmmm,

❝ We received then and when (not so seldom!) questions about the ANOVA F-test results. Up to the request to comment significant results even for the treatment effects, of no relevance in case of BE studies of course.

❝ Nasty the requests to comment the "validity" of the BE evaluation if period and/or sequence effects are found significant. As they many times come out if Type I tests will be applied, especially for sequence.

Why not just always fit the model with no intercept and type I. The first term is almost guaranteed to have a significant P-value. You can then discuss it as much as you feel like at the nuisance level. Specify Sequence first, and voila here's a nice discussion brewing already :-D

You can have a standard answer ready for all procedures.

—
Pass or fail!
ElMaestro

Complete thread:

R code for lm.mod does not make sense dmfisher 2015-06-09 03:55
- R code for lm.mod does not make sense yjlee168 2015-06-09 17:57
  - R code for lm.mod does not make sense ElMaestro 2015-06-09 21:07
    - R code for lm.mod does not make sense yjlee168 2015-06-10 11:34
      - R code for lm.mod does not make sense ElMaestro 2015-06-10 14:22
        
        R code for lm.mod does not make sense yjlee168 2015-06-11 09:44
        
        Reference datasets Helmut 2015-06-11 11:50
        
        Reference datasets ElMaestro 2015-06-11 12:01
        
        Reference datasets yjlee168 2015-06-11 22:16
        Type III kuddel muddel d_labes 2015-06-12 09:04
        
        Type III kuddel muddel Helmut 2015-06-12 11:27
        
        ANOVA F-test results and regulators d_labes 2015-06-12 15:23
        
        ANOVA F-test results and regulatorsElMaestro 2015-06-12 15:29
        
        ANOVA F-test results and regulators d_labes 2015-06-12 15:44
        
        ANOVA F-test results and regulators ElMaestro 2015-06-12 15:52
        
        Type III again ElMaestro 2015-06-12 12:18
        
        SAS OT d_labes 2015-06-12 15:32
        
        Reference datasets yjlee168 2015-06-11 19:56
        Test hypothesis of using Type I/III MS... yjlee168 2015-06-12 09:01
  - R code for lm.mod does not make sense dmfisher 2015-06-10 01:38