Bioequivalence and Bioavailability Forum • Bugs fixed in bear?

Bugs fixed in bear? [🇷 for BE/BA]

posted by yjlee168 – Kaohsiung, Taiwan, 2015-04-17 03:21 (3718 d 01:16 ago) – Posting: # 14693
Views: 29,868
(edited on 2015-04-17 12:53)

Dear mittyri and Helmut,

I would like to respond all questions in this thread.

There is still no way (so far) to validate bear with WNL or SAS when analyzing replicate data set since the differences of mixed model applied between R (lme) and SAS (PROC MIXED) or WNL (same as SAS?). The issue has been discussed a lots in this forum.
The error reported by Helmut has been fixed. It is due to the error of parameter transfer between built functions. It affects replicate and parallel data analysis. The correct one should be

Dependent Variable: log(Cmax) -------------------------------------- n1(seq 1)= 7 n2(seq 2)= 7 N(n1+n2) = 14 Lower criteria = 80.000 % Upper criteria = 125.000 % MEAN-ref = 7.326071 MEAN-test = 7.39 SE = 0.04758714 Estimate(test-ref) = 0.06373952
The data loading error as in Fdata[[1]] : subscript out of bounds: I am still working on it. Now loading data is OK. But need more tests. Omitting NA in R, it will delete the entire row (i.e. data of an entire period). The error is caused by applying NA omit after loading data. Thus everything is gone since all AUC_0-t and AUC_0-inf are NAs. The other thing is that using semicolon as the separator in a *.csv dataset for import with bear may not work properly. If so, consider to use comma as the separator instead semicolon. I still don't know why.
Hopefully all these can be done for next release (v2.6.5).

That's all. Have a nice weekend.

—
All the best,
-- Yung-jin Lee
bear v2.9.2:- created by Hsin-ya Lee & Yung-jin Lee
Kaohsiung, Taiwan https://www.pkpd168.com/bear
Download link (updated) -> here

Thread locked

Complete thread:

Reproducing Bear results in Phoenix mittyri 2015-04-14 08:35
- Bug in bear? Helmut 2015-04-14 14:07
  - Bug in bear? mittyri 2015-04-14 20:43
    - Bug in bear? Helmut 2015-04-15 02:17
  - use the same dataset? yjlee168 2015-04-20 10:13
- Bugs in bear with replicated demo data set? yjlee168 2015-04-15 09:38
- Bugs fixed in bear?yjlee168 2015-04-17 01:21
  - Bugs fixed in bear? Helmut 2015-04-17 14:25
    - Bugs fixed in bear? yjlee168 2015-04-17 18:50
      - Bugs fixed in bear? ElMaestro 2015-04-17 23:14
        
        lme() in bear yjlee168 2015-04-18 11:12
        
        lme() in bear ElMaestro 2015-04-18 11:28
        
        lme() in bear yjlee168 2015-04-18 12:02
        
        lme() in bear ElMaestro 2015-04-18 13:42
        
        Mean means Helmut 2015-04-18 14:08
        
        Mean means ElMaestro 2015-04-18 16:01
        
        Mean means Helmut 2015-04-19 00:59
        
        Mean means ElMaestro 2015-04-19 09:14
        
        LL and AIC Helmut 2015-04-19 11:08
        
        Confused ElMaestro 2015-04-19 11:42
        
        lsmeans for mixed model in R yjlee168 2015-04-19 23:36
        
        lsmeans() & lme() Helmut 2015-04-20 01:28
        
        lsmeans() & lme() yjlee168 2015-04-20 10:23
        lsmeans() & lme() ElMaestro 2015-04-20 10:35
        
        keep it simple! Helmut 2015-04-20 14:34
        
        keep it simple! ElMaestro 2015-04-20 15:39
        
        ML vs. REML Helmut 2015-04-20 16:35
        
        lme() with NA in R yjlee168 2015-04-19 23:44
      - Dataset Helmut 2015-04-18 13:30
        
        Dataset and lme() in bear yjlee168 2015-04-18 23:14