Bioequivalence and Bioavailability Forum • Bug in bear?

Bug in bear? [🇷 for BE/BA]

posted by mittyri – Russia, 2015-04-14 22:43 (4084 d 00:16 ago) – Posting: # 14688
Views: 33,726

Guten Abend!

❝ Bad news: Something seems to be strange in bear.

I'm a little bit surprised. No validation was performed for replicate design? I've found the validation report only for 2X2X2 crossover (dated 2009)
I know that some companies use Bear for BE estimation during the registration procedure. No statistical validation after installation?

❝ The dataset looks artificial to me – in most cases exactly ±10 in the respective periods…

The author of the package mentioned that these demo sets aren't artificial

—
Kind regards,
Mittyri

Thread locked

Complete thread:

Reproducing Bear results in Phoenix mittyri 2015-04-14 08:35
- Bug in bear? Helmut 2015-04-14 14:07
  - Bug in bear?mittyri 2015-04-14 20:43
    - Bug in bear? Helmut 2015-04-15 02:17
  - use the same dataset? yjlee168 2015-04-20 10:13
- Bugs in bear with replicated demo data set? yjlee168 2015-04-15 09:38
- Bugs fixed in bear? yjlee168 2015-04-17 01:21
  - Bugs fixed in bear? Helmut 2015-04-17 14:25
    - Bugs fixed in bear? yjlee168 2015-04-17 18:50
      - Bugs fixed in bear? ElMaestro 2015-04-17 23:14
        
        lme() in bear yjlee168 2015-04-18 11:12
        
        lme() in bear ElMaestro 2015-04-18 11:28
        
        lme() in bear yjlee168 2015-04-18 12:02
        
        lme() in bear ElMaestro 2015-04-18 13:42
        
        Mean means Helmut 2015-04-18 14:08
        
        Mean means ElMaestro 2015-04-18 16:01
        
        Mean means Helmut 2015-04-19 00:59
        
        Mean means ElMaestro 2015-04-19 09:14
        
        LL and AIC Helmut 2015-04-19 11:08
        
        Confused ElMaestro 2015-04-19 11:42
        
        lsmeans for mixed model in R yjlee168 2015-04-19 23:36
        
        lsmeans() & lme() Helmut 2015-04-20 01:28
        
        lsmeans() & lme() yjlee168 2015-04-20 10:23
        lsmeans() & lme() ElMaestro 2015-04-20 10:35
        
        keep it simple! Helmut 2015-04-20 14:34
        
        keep it simple! ElMaestro 2015-04-20 15:39
        
        ML vs. REML Helmut 2015-04-20 16:35
        
        lme() with NA in R yjlee168 2015-04-19 23:44
      - Dataset Helmut 2015-04-18 13:30
        
        Dataset and lme() in bear yjlee168 2015-04-18 23:14