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RegisterHow to use Bear for sample size calculation for Xover study [🇷 for BE/BA]
How to use Bear for sample size calculation for Crossover study 2x2, power=80, CVintra=.16, BE margins=80-125
description_size
function (parallel = FALSE)
{
cat("\n")
cat("****************************************************************************\n")
cat(" Required data \n")
cat("----------------------------------------------------------------------------\n")
cat(" 1. Theta (%): the target ratio in average BA between the two formulations\n")
cat(" expressed in percentage of the average reference BA. \n")
cat(" 2. Power (%): the least statistical power to detect (1-Power) \n")
cat(" differences between the Test and the Reference formulation. \n")
if (parallel) {
cat(" 3. CV (%): the inter-subject coefficient of variation for parallel \n")
cat(" study. \n")
}
else {
cat(" 3. CV (%): the intra-subject coefficient of variation for crossover \n")
cat(" (or replicate crossover) study. \n")
}
cat(" 4. Lower acceptance limit represents the lower BE criteria to be accepted; \n")
cat(" the upper acceptance limit is equal to 1/(lower acceptance limit). \n")
cat(" Usually the lower limit can be 80.000% or, 70.000% in some cases. \n")
cat("****************************************************************************\n")
cat("\n")
readline(" Press Enter to proceed...")
}
<environment: namespace:bear>Complete thread:
- How to use Bear for sample size calculation for Xover studyxtianbadillo 2014-12-12 07:27
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Sample size estimation in bear and PowerTOST Helmut 2014-12-12 13:50
- Sample size estimation in bear and PowerTOST nobody 2014-12-12 14:24
- Sample size estimation in bear and PowerTOST Helmut 2014-12-12 14:49
- Sample size estimation in bear and PowerTOST yjlee168 2014-12-13 17:26
- Sample size estimation in bear and PowerTOST nobody 2014-12-12 14:24
- Sample size estimation in bear and PowerTOST Helmut 2014-12-12 13:50
Ing. Helmut Schütz