Bioequivalence and Bioavailability Forum • Difficulties with NCA BEAR

Difficulties with NCA BEAR [🇷 for BE/BA]

posted by PK_Lover – Portugal, 2014-11-22 01:07 (3863 d 15:41 ago) – Posting: # 13911
Views: 17,996

Dear yjlee168,

thank you very much for your quick reply (I am honored!).

I am sorry for not replying earlier but I did not have access to the station where I have R installed until now.

Here is the setup (it is the default):

Methods Setting which_is
1 run demo? 0 no
2 study design? 0 2x2x2 crossover
3 single-/multiple-dose 0 single-dose
4 lambda_z estimate 0 adj. R sq. (ARS)
5 trapezoidal AUC 0 linear-up/log-down
6 BE criterion (LL) 80 lower limit
7 ODA? 0 no
8 dose? 100000 dose given
9 dosing interval 24 *multiple-dose only
10 Tlast 120 *multiple-dose only
11 pAUC? 0 all AUC
12 pAUC_start 121 the starting time of pAUC
13 pAUC_end 128 the end time of pAUC
14 IDP output? 0 no

The plot label of x-axis -> Time after Dosing (hr)
and the label of y-axis -> DrugX Plasma Conc. (ng/mL)

And I am using data from a simple Crossover design with 2 periods, single administration.

Complete thread:

Difficulties with NCA BEAR PK_Lover 2014-11-21 00:28
- Difficulties with NCA BEAR yjlee168 2014-11-21 07:34
  - Difficulties with NCA BEARPK_Lover 2014-11-22 00:07
    - Difficulties with NCA BEAR yjlee168 2014-11-22 03:21
      - Difficulties with NCA BEAR PK_Lover 2014-11-22 09:47
        
        help test NCA BEAR yjlee168 2014-12-01 08:13
        
        help test NCA BEAR Emrah Soner Özdeş 2015-01-15 14:37
        
        help test NCA BEAR Jam 2015-01-23 08:55
        
        CSV files with a comma at the end of each line? yjlee168 2015-01-25 04:35
      - Difficulties with NCA BEAR xtianbadillo 2016-09-15 22:44
        
        old bear and friends yjlee168 2016-09-16 09:42
        
        old bear and friends VStus 2016-09-26 13:30
        
        multiple-dosed study with bear yjlee168 2016-09-26 18:04
        
        multiple-dosed study with bear VStus 2016-10-11 09:01
        
        multiple-dosed study with bear yjlee168 2016-10-11 10:15
        
        multiple-dosed study with bear VStus 2016-10-11 10:37
        multiple-dosed study with bear VStus 2016-10-12 10:37
        
        multiple-dosed study with bear [solved] yjlee168 2016-10-12 18:42