Bioequivalence and Bioavailability Forum • Difficulties with NCA BEAR

Difficulties with NCA BEAR [🇷 for BE/BA]

posted by PK_Lover – Portugal, 2014-11-21 01:28 (4231 d 12:33 ago) – Posting: # 13895
Views: 23,309

Hello all,

I am trying BEAR for the first time for a simple NCA and ANOVA analysis for a 2x2x2 BE study data.

I have arranged all the data in a .csv file with subj,seq,perd,time,conc and I have maintained T0=0 and all the other LLOQ (either at the start of the schedule or at the end) as NA.

I ran BEAR, import the file, the values appear correctly in the table. It starts the analysis, it shows some pk values but then states:

Error in lm.fit(x, y, offset = offset, singular.ok = singular.ok, ...) : 

  NA/NaN/Inf in 'y'

and crashes. I have checked all the data, seems ok.

Could you please help me and tell me whats wrong?

Thank you!

Complete thread:

Difficulties with NCA BEARPK_Lover 2014-11-21 00:28
- Difficulties with NCA BEAR yjlee168 2014-11-21 07:34
  - Difficulties with NCA BEAR PK_Lover 2014-11-22 00:07
    - Difficulties with NCA BEAR yjlee168 2014-11-22 03:21
      - Difficulties with NCA BEAR PK_Lover 2014-11-22 09:47
        
        help test NCA BEAR yjlee168 2014-12-01 08:13
        
        help test NCA BEAR Emrah Soner Özdeş 2015-01-15 14:37
        
        help test NCA BEAR Jam 2015-01-23 08:55
        
        CSV files with a comma at the end of each line? yjlee168 2015-01-25 04:35
      - Difficulties with NCA BEAR xtianbadillo 2016-09-15 22:44
        
        old bear and friends yjlee168 2016-09-16 09:42
        
        old bear and friends VStus 2016-09-26 13:30
        
        multiple-dosed study with bear yjlee168 2016-09-26 18:04
        
        multiple-dosed study with bear VStus 2016-10-11 09:01
        
        multiple-dosed study with bear yjlee168 2016-10-11 10:15
        
        multiple-dosed study with bear VStus 2016-10-11 10:37
        multiple-dosed study with bear VStus 2016-10-12 10:37
        
        multiple-dosed study with bear [solved] yjlee168 2016-10-12 18:42