Bioequivalence and Bioavailability Forum

Dear All,

We would like to estimate the power of a BE study that has been completed. The no of subjects enrolled was 28 but 3 dropped out. Hence, left only 25 subjects.

In R-Software, we key the data using two different approaches :-
No 1
power.TOST(CV=0.29, n=25, theta0=0.95)
[1] 0.618512

No 2
power.TOST(CV=0.29, n=25, theta0=0.95, theta1=0.83, theta2=1.09)
[1] 0.07853425

Which is the right way to key in data ? The first one or the second one ?
Do we have to key in the value of lower and upper BE limit obtained from the study ? Why after putting in the lower and upper BE limit, the power is only about 8% versus 62%.

Your input is highly appreciated.

Thank you.

Regards,
Ken

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Edit: Category changed. [Helmut]