Bioequivalence and Bioavailability Forum • Geometric mean in plots

Geometric mean in plots [🇷 for BE/BA]

posted by yjlee168 – Kaohsiung, Taiwan, 2013-03-27 22:16 (4830 d 07:19 ago) – Posting: # 10300
Views: 14,022

Dear Helmut,

Thanks for your messages. Yes, I do plot the conc. vs. time on a semilog scale with mean + sd. Hopefully, I wish that I have fixed bear to take care of this, such as using 'foo <- na.omit(foo)' for conc. < LLOQ. And I find the package I used (sciplot) can ignore the data point with value of zero (the first data point). For some reasons (which I still cannot figure out), semilog plots do not show at all, specially for multiple-dose, parallel study. I don't know if it is data dependent. However, the linear plots always works very well. Probably, I should consider to include both linear and semilog plots.

❝ Problems arise if at least one concentration is <LLOQ. Some people (like me) don’t report the geometric mean for this time point, others calculate the mean if ⅔ or ½ of concentrations are >LLOQ (excluding the BQLs). For the plots I would suggest to use backtransformed values – either in linear scale or with a log-axis.

—
All the best,
-- Yung-jin Lee
bear v2.9.6:- created by Hsin-ya Lee & Yung-jin Lee
Kaohsiung, Taiwan https://www.pkpd168.com/bear
Download link (updated) -> here

Complete thread:

Bear: feature requests Helmut 2010-12-08 15:48
- Bear: feature requests yjlee168 2010-12-08 18:49
  - Bear: feature requests Helmut 2010-12-08 19:48
  - Bear: feature requests d_labes 2010-12-09 08:48
    - Bear: feature requests Helmut 2010-12-09 14:20
      - Bear: feature requests yjlee168 2010-12-09 20:24
    - Bear: feature requests yjlee168 2010-12-09 19:57
      - Bear: feature requests Aceto81 2010-12-13 10:26
        
        Bear: feature requests yjlee168 2010-12-13 13:29
- Geometric mean? re: Bear: feature requests yjlee168 2013-03-27 13:21
  - Geometric mean in plots Helmut 2013-03-27 14:18
    - Geometric mean in plotsyjlee168 2013-03-27 21:16