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RegisterCVinter zero?! [General Statistics]
posted by Helmut 
– Vienna, Austria, 2012-08-20 01:57 (5047 d 12:14 ago) – Posting: # 9083
Views: 3,539
Hi Ioana!
The former is nice to know and only the latter needed for scaling.
That’s a crude estimate of CVtotal. Its value could only be identical to CVintra if CVinter = 0… I guess the CRO screwed up.
Unlikely, but not impossible. Comparisons (especially of HVDs/HVDPs) between study are always problematic. BTW, do you trust in their bioanalytics?
❝ The CRO reported also the values obtained for intra- subject variability for test and also for reference product.
The former is nice to know and only the latter needed for scaling.
❝ But the reported value is identical with Geo CV of mean Cmax for the tested products.
That’s a crude estimate of CVtotal. Its value could only be identical to CVintra if CVinter = 0… I guess the CRO screwed up.
❝ More than that, these values are almost double compared to those reported for reference in literature.
Unlikely, but not impossible. Comparisons (especially of HVDs/HVDPs) between study are always problematic. BTW, do you trust in their bioanalytics?
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Complete thread:
- within - subject variability ioanam 2012-08-19 08:54
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- CVinter zero?!Helmut 2012-08-19 23:57
- CVinter zero?! ioanam 2012-08-21 08:55
- CVinter zero?!Helmut 2012-08-19 23:57
Ing. Helmut Schütz