Bioequivalence and Bioavailability Forum

maths versus understanding [General Statistics]

posted by msmnainar – India, 2012-06-25 13:26 (5103 d 01:48 ago) – Posting: # 8843
Views: 7,959

Dear ElMaestro

❝ ❝ A plot of Ceq/(x/m) versus Ceq was depicted to obtain k1 and k2 values.

❝ Please explain the bold part.

Obtained Total Unbound Bile acid Concentration, mM (ceq)

Obtained Total Bound Bile acid Concentration, mM (x/m)

❝ What do you wish to back-calculate? And when you do it, which is the input parameter (and at which value) that you want an output from?

The results obtained from Langmuir equation (Ceq/(x/m) =1/k1.k2+Ceq/k2) to be back calculated.

Inputs are,

k1 = 1.2071
k2 = 5.4189

Obtained Ceq values for 9 different concentrations, mean and sum values are presented below,

Concentration   (ceq)

     1          0.7409

     2          1.0893

     3          1.7033

     4          2.6475

     5          5.1578

     6          8.7521

     7         14.161

     8         19.233

     9         25.3301

Mean            8.7572

Sum            78.815

Obtained Ceq/(x/m) values

Concentration   Ceq/(x/m)

     1           0.5882

     2           0.5699

     3           0.5165

     4           0.6081

     5           1.0647

     6           1.4001

     7           2.4236

     8           3.3321

     9           5.4172

—
Sundar. M

Complete thread:

Back calculation for QC purpose msmnainar 2012-06-24 09:06
- Back calculation for QC purpose ElMaestro 2012-06-24 11:12
  - Back calculation for QC purpose msmnainar 2012-06-25 05:12
  - Back calculation for QC purpose msmnainar 2012-06-25 08:46
    - maths versus understanding ElMaestro 2012-06-25 10:36
      - maths versus understanding msmnainar 2012-06-25 10:59
        
        maths versus understanding ElMaestro 2012-06-25 11:03
        
        maths versus understandingmsmnainar 2012-06-25 11:26
    - Back calculation for QC purpose ElMaestro 2012-06-25 11:35
      - Back calculation for QC purpose msmnainar 2012-06-25 12:00
        
        Back calculation for QC purpose ElMaestro 2012-06-25 13:19

maths versus understanding [General Sta­tis­tics]

Complete thread:

maths versus understanding [General Statistics]