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RegisterBack calculation for QC purpose [General Statistics]
Dear ElMaestro
Post to your response am having few queries reg back calculation, kindly guide me,
For eg.,
Obtained Total Bound Bile acid Concentration, mM (x/m)
Obtained Total Unbound Bile acid Concentration, mM (ceq)
Obtained k1 and k2 values:
k1 = 1.2071
k2 = 5.4189
Back calculated value for Ceq = 2.9970 using mean data (x/m), as per the provided formula
C = (1/(k1k2))/((1/(x/m)-1/k2))
Kindly guide me, if am correct this value should matches with obtained Ceq value for product x mean value or any further comparison should be done.
----------
Hello Helmutji
It was very nice to meet you at Budapest during 3rd international regulatory conference. Need your expertise in this regard.
Post to your response am having few queries reg back calculation, kindly guide me,
For eg.,
Obtained Total Bound Bile acid Concentration, mM (x/m)
Concentration Product X
1 1.2595
2 1.9113
3 3.2978
4 4.3539
5 4.8442
6 6.251
7 5.843
8 5.772
9 4.6759
Mean 4.2454
Sum 38.2086Obtained Total Unbound Bile acid Concentration, mM (ceq)
Concentration Product X
1 0.7409
2 1.0893
3 1.7033
4 2.6475
5 5.1578
6 8.7521
7 14.161
8 19.233
9 25.3301
Mean 8.7572
Sum 78.815Obtained k1 and k2 values:
k1 = 1.2071
k2 = 5.4189
Back calculated value for Ceq = 2.9970 using mean data (x/m), as per the provided formula
C = (1/(k1k2))/((1/(x/m)-1/k2))
Kindly guide me, if am correct this value should matches with obtained Ceq value for product x mean value or any further comparison should be done.
----------
Hello Helmutji
It was very nice to meet you at Budapest during 3rd international regulatory conference. Need your expertise in this regard.
—
Sundar. M
Sundar. M
Complete thread:
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- Back calculation for QC purpose ElMaestro 2012-06-24 11:12
- Back calculation for QC purpose msmnainar 2012-06-25 05:12
- Back calculation for QC purposemsmnainar 2012-06-25 08:46
- maths versus understanding ElMaestro 2012-06-25 10:36
- maths versus understanding msmnainar 2012-06-25 10:59
- maths versus understanding ElMaestro 2012-06-25 11:03
- maths versus understanding msmnainar 2012-06-25 11:26
- maths versus understanding ElMaestro 2012-06-25 11:03
- maths versus understanding msmnainar 2012-06-25 10:59
- Back calculation for QC purpose ElMaestro 2012-06-25 11:35
- Back calculation for QC purpose msmnainar 2012-06-25 12:00
- Back calculation for QC purpose ElMaestro 2012-06-25 13:19
- Back calculation for QC purpose msmnainar 2012-06-25 12:00
- maths versus understanding ElMaestro 2012-06-25 10:36
- Back calculation for QC purpose ElMaestro 2012-06-24 11:12
Ing. Helmut Schütz