Bioequivalence and Bioavailability Forum

Dear ELMaestro,

Thanks for your suggestion.

The only concern we gave that if we are evaluating the group effect in both ways i.e.'Center' as group factor as primary analysis and 'month' as group factor as secondary analysis, if one of the evaluation is shown the existence of group effect and another doesn't, then what should be our conclusion. For example if group effect is shown for data between month and for 'center' no such effect is observed, then can we conclude that there is no group effect and combine the data of all 5 group (each for one center) for statistical analysis? If the situation is reverse i.e group effect is not shown secondary analysis(month) & shown for 'center', what would be our conclusion & action plan? Kindly advise.