Bioequivalence and Bioavailability Forum

How many subjects? [General Sta­tis­tics]

posted by jdetlor – 2011-05-02 20:21 (5523 d 11:32 ago) – Posting: # 6977
Views: 13,462

Dear d_labes, Dear All!

d_labes this is an excellent reply IMHO.

The only addition I would make would be to point out that the SUBJ= option in the RANDOM statement is absent from the second set of code. This is critical to the proper allocation of the between and within variabilities. If we ignore this option in the RANDOM statement we are assuming the data is from 1 subject only, and thus the G matrix is not in a block-diagonal format. The data from each subject in our actual dataset is not treated as independent, and our between-subject variabilities are reduced, while our within-subject variabilities are increased.

I would guess this is the case with randombadger's results.

J. Detlor

Complete thread:

• Replicate Designs & IntraSubj CV randombadger 2011-04-28 13:02 
  • Replicate Designs & IntraSubj CV Helmut 2011-04-28 15:00
    • Replicate Designs & IntraSubj CV randombadger 2011-04-28 15:25
      • Replicate Designs & IntraSubj CV Helmut 2011-04-28 17:09
      • Inter-subject dance with the wolves d_labes 2011-04-29 11:33
        • How many subjects?jdetlor 2011-05-02 18:21
          • G matrix d_labes 2011-05-03 08:26
            • G matrix ElMaestro 2011-05-03 09:15
              • G matrix d_labes 2011-05-03 09:51
                • Results randombadger 2011-05-03 12:03
                  • Results - comments d_labes 2011-05-03 14:32
                    • Results - comments randombadger 2011-05-03 16:53
                      • Lost cents d_labes 2011-05-04 08:07
                • G matrix ElMaestro 2011-05-03 14:16
            • G matrix jdetlor 2011-05-03 19:37