Replicate Designs & IntraSubj CV [General Sta­tis­tics]

posted by Helmut Homepage – Vienna, Austria, 2011-04-28 19:09 (5526 d 22:14 ago) – Posting: # 6968
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Dear randombadger!

❝ We're using TRR, RTT design.


I see. The “extra-reference design”. Not optimal because biased in the presence of period effects.

❝ I suspect they're adding the carryover based on the SC Chow & JP Liu section on 2 sequence dual designs but yes, I plan to discuss with them their thinking behind the RANDOM statement as it's same as you'd use for a 2x2 XO design.


With your code and Chow/Liu’s Table 9.3.3 untransformed data, I can reproduce their CI of (-1.48, 2.83), whilst FDA’s code gets hickups (Newton's algorithm converged with modified Hessian. Output is suspect.) and gives a much wider CI (-5.62, 6.97). BTW, I’m using Phoenix6.2; last post from my side, I guess we need a SAS-guru here (Detlew, are you here?).

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