Bioequivalence and Bioavailability Forum

normocaloric vs high fat meal [General Sta­tis­tics]

posted by Helmut  – Vienna, Austria, 2010-12-15 18:03 (5662 d 08:11 ago) – Posting: # 6310
Views: 5,628

Dear D. Labes!

❝ Ok. I understand . But this relies on the assumption of no period

❝ effect I think?

Yes. But there are similar designs commonly applied. Think about a PK study where we compare MD profiles with the first SD profiles. That's a paired design, but (has to) assume no period effect as well.

❝ What do you think about an evaluation via incomplete blocks cross-over (I

❝ hope the terminus is the correct one )? I.e.

❝ 4-treatment-4-sequence-2-period cross-over. T1, R1 are under normocaloric

❝ conditions, T2, R2 under high-fat.

Nice question, next question.
But I guess that should be possible.

—
Dif-tor heh smusma 🖖🏼 Довге життя Україна! 
Helmut Schütz


The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

• normocaloric vs high fat meal Dr_Dan 2010-12-15 09:49 
  • normocaloric vs high fat meal Helmut 2010-12-15 13:50
    • normocaloric vs high fat meal d_labes 2010-12-15 15:37
      • normocaloric vs high fat meal Helmut 2010-12-15 16:10
        • normocaloric vs high fat meal d_labes 2010-12-15 16:53
          • normocaloric vs high fat mealHelmut 2010-12-15 17:03
    • normocaloric vs high fat meal Dr_Dan 2010-12-15 16:33