Bioequivalence and Bioavailability Forum

BE parallel design [General Sta­tis­tics]

posted by Jaime_R – Barcelona, 2007-04-03 20:58 (7015 d 07:36 ago) – Posting: # 617
Views: 23,900

Hi PKPDPKPD - what a nick!

❝ While assessing BE in two-group parallel design study, should one use nominal data or log transformed data.

Log-transformed if you are applying a multiplicative model (for all clearance based parameters, e.g., for AUC, Cmax,...)
Untransformed for Tmax - if applicable to your formulation.

❝ If log transformed, should it be log or ln?

Whatever you like (ld - logarithmus dualis - would also do the job), but most people prefer ln.

Complete thread:

• BE parallel design pkpdpkpd 2007-04-03 17:45 
  • BE parallel designJaime_R 2007-04-03 18:58
    • BE parallel design pkpdpkpd 2007-04-03 19:07
      • BE parallel design Jaime_R 2007-04-03 19:41
        • BE parallel design pkpdpkpd 2007-04-03 20:14
          • BE parallel design Jaime_R 2007-04-03 20:29
            • BE parallel design pkpdpkpd 2007-04-03 21:48
              • BE parallel design Jaime_R 2007-04-04 15:14
                • BE parallel design Helmut 2007-04-04 15:31
                  • BE parallel design pkpdpkpd 2007-04-04 17:32
                  • BE parallel design Jaime_R 2007-04-04 20:33
                • BE parallel design Sathya 2008-09-01 07:21
                • BE parallel design Sathya 2008-09-04 12:37