Bioequivalence and Bioavailability Forum

dear all!

thank you very much for your valuable comments. HS won the bet; its a toxicokinetic (TK) study which characterize ADME/exposure in toxicity species with doses at toxicological levels.

Toxicokinetics can be regarded as an expansion of PK as it is rather unrealistic assuming similar PK processes with toxicological doses than with therapeutic doses as the ability of the body to cope with a compound is extended to the limit (Welling, 1995)

best regards

martin

Welling PG (1995). Difference between Pharmacokinetics and Toxicokinetics. Toxicol Pathol 23(2):143-147.