Bioequivalence and Bioavailability Forum

SAS and/or Phoenix/WinNonlin-experts around? [General Statistics]

posted by Helmut – Vienna, Austria, 2010-07-13 04:29 (5822 d 02:43 ago) – Posting: # 5613
Views: 17,027

Dear Paolo!

Had a quick look in Phoenix6.1 (average BE, too late to get FDA's model running).
Fixed: SEQUENCE+TREATMEN+PERIOD
Repeated Specification:
PERIOD
Variance Blocking Variables (Subject): SUBJECT
Group: TREATMEN
Type: Variance Components
Random Effects: TREATMEN
Variance Blocking Variables (Subject): SUBJECT
Type: Banded No-Diagonal Factor Analytic (f)
Number of factors (f): 2

I got:

Warning 11091: Newton's algorithm converged with modified Hessian. Output is suspect.

Model may be over-specified. A simpler model could be tried.

and sigma²_WR 0.1861995 (CV_WR 0.452397)

If I try IBE/PBE I got:

*** WARNING 11121: Subject X had incomplete design and was discarded.

*** WARNING 11122: Sequence RTR had less than two complete subjects and was discarded.

*** WARNING 11122: Sequence TRR had less than two complete subjects and was discarded.

*** ERROR 11107: Fewer than two sequences had complete design. Program termininating.

X in the warning above is the ID of all subjects except ones in sequence RRT. That was it. :confused:

P.S.: Please delete anything from the text of the original poster which is not necessary in understanding your answer; see also this post!

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Helmut Schütz

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Complete thread:

SABE Reference Variability and CI Computation preyes323 2010-07-12 17:12
- Dataset Helmut 2010-07-12 17:26
  - Dataset preyes323 2010-07-12 18:20
    - Data format Helmut 2010-07-12 18:38
      - Data format preyes323 2010-07-13 01:16
        
        SAS and/or Phoenix/WinNonlin-experts around?Helmut 2010-07-13 02:29
        
        Phoenix/WinNonlin-experts around? d_labes 2010-07-13 12:15
        
        Phoenix/WinNonlin-experts around? Helmut 2010-07-13 13:42
        
        Mixed interest d_labes 2010-07-13 15:11
        
        Mixed interest Helmut 2010-07-13 19:19
        
        lme() answer and beyond ... d_labes 2010-07-14 10:41
        
        lme() answer and beyond ... Helmut 2010-07-14 13:47
        
        AIC, BIC and that all ... d_labes 2010-07-15 12:01
        
        To Err is Human d_labes 2010-07-13 11:51
        
        To Err is Human, but... Helmut 2010-07-13 13:45
        
        ... to Arr is Pirate d_labes 2010-07-13 15:47
        
        Brilliant page!!! ElMaestro 2010-07-14 21:03
        
        To Err is Human preyes323 2010-07-14 14:45
        
        Heads up! Helmut 2010-07-14 15:17
        To Err is Teacher d_labes 2010-07-15 11:05
        
        To Err is Human preyes323 2010-07-16 02:28
        
        To Err is Human d_labes 2010-07-16 10:42
        
        To Err is Human preyes323 2010-07-17 11:14
        
        Regulatory constants d_labes 2010-07-19 10:00
        
        Data format ElMaestro 2011-02-06 11:54
        
        SAS System Viewer Helmut 2011-02-06 13:02

SAS and/or Phoenix/WinNonlin-experts around? [General Sta­tis­tics]

Complete thread:

SAS and/or Phoenix/WinNonlin-experts around? [General Statistics]