Bioequivalence and Bioavailability Forum

Dear Dr Dan and Helmut

Then what will be the possible solution?

My query was influenced beacuse of logistical reasons. For e.g: If we have a study with 80-90 as the sample size and we have sampling to be done frequently (e.g. at 5 minute intervals), we need high number of personnel/resources. So we can utilize the minimal resource and use the same resource on the same day for a different group.

Is there an alternative for such a design henceforth?

And AFAIG, your reply does signify that even we dose two groups at different time sets on the single day, we will have to use group-effect as we have lot many parameters getting changed in the two groups.