Bioequivalence and Bioavailability Forum

many ANOVA but only one trial [General Statistics]

posted by boonchai_l – Thailand, 2010-05-24 13:53 (5869 d 08:45 ago) – Posting: # 5368
Views: 15,591

Dear All,

According to above recommendations for 4-way crossover study, I am a little bit weird because we were planning to conduct at least two ANOVA tables from only one trial.

This is a possible example.

The overall ANOVA may be produced to tell that there is any significance, the formulation may be a main effect and food is block effect, something like this... but any variance in this ANOVA is not suitable to conduct 90%CI to prove equivalence in both conditions. So
Some data in some periods and sequences are selected to produce ANOVA for obtaining the MSE to conduct 90%CI of T/R ratio under fed condition. and
Some data in some periods and sequences are selected to produce ANOVA for obtaining the MSE to conduct 90%CI of T/R ratio under fasting condition.

BTW: The major objective of most study for both of clinical or non-clinical experiment is to prove the difference among treatments. The F statistic can tell whether that difference is significant. And some contrast may be set to prove significance in some interesting condition.

Unlike bioequivalence study, it is for proving equivalence. So the F and ANOVA are not the answer to prove equivalence BUT the thing everyone needs to know is whether 90%CI is in 80-125%.

Best Regards,
BL

Complete thread:

4-period BE study fed/fasting: statistical issues Amandine 2009-06-04 12:31
- Confounded effects; common variance Helmut 2009-06-04 12:55
  - Neglecting period effects? d_labes 2009-06-10 10:10
    - Assumptions... Helmut 2009-06-23 14:38
  - What if... Ohlbe 2010-03-10 14:27
    - What if... Dr_Dan 2010-03-11 15:50
      - What if… Helmut 2010-03-11 16:39
        
        What if… Dr_Dan 2010-03-12 08:49
        
        Need-to-know / nice-to-know Helmut 2010-03-12 11:35
        
        many ANOVA but only one trialboonchai_l 2010-05-24 11:53
        
        many ANOVA but only one trial GSTATS 2010-06-08 21:52

many ANOVA but only one trial [General Sta­tis­tics]

Complete thread:

many ANOVA but only one trial [General Statistics]