Bioequivalence and Bioavailability Forum

Meta-analysis alpha [General Sta­tis­tics]

posted by Helmut  – Vienna, Austria, 2010-04-12 16:25 (5913 d 16:00 ago) – Posting: # 5088
Views: 10,546

Dear D. Labes!

Agree with your points (e.g., not confirmatory). I did not know this EMA-document, THX.
Interesting Section II.1.3:

A retrospective meta-analysis of only two studies originally intended to stand on their own is not expected to add any useful information. In particular, a meta-analysis can­not be used to reconcile the conflicting results of one positive and one inconclusive study.

❝ BTW: I would incorporate a treatment by study interaction in the model as test of heterogeneity.

OK.

❝ BTW2: What big differences did you expect with such a very low intra-subject variability?

I didn't expect anything. This was just the only dataset I had coming closest to two identical studies. As said in my previous post it is unlikely to repeat a study with any modifications.

❝ BTW3: See Chow/Liu "Design and Analysis ...", Chapter 16 "Meta-analysis for bioequivalence review" to be more confused .

Oh.

—
Dif-tor heh smusma 🖖🏼 Довге життя Україна! 
Helmut Schütz


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