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RegisterSequential design = opportunity (IMHO) [General Statistics]
Dear Helmut
I totally agree: Sequential design = opportunity. If I plan to be BE in the first stage, and my assumptions are fulfilled - everything is perfect.
There is no right or wrong. Your decision how to plan the study will depend on the risk you want to take, the time you need for the study and the money that you have to spend.
In Boonchai's example there's a limit in the clinical capacity. His expected sample size is 80 and he has only the option to start with 40. What do you think about a replicate design study? A replicate design study with 40 subjects will be better than a two way cross-over study with 80 subjects devided into two groups since you can claim the widened acceptance range for Cmax.
Kind regards
Dan
I totally agree: Sequential design = opportunity. If I plan to be BE in the first stage, and my assumptions are fulfilled - everything is perfect.
There is no right or wrong. Your decision how to plan the study will depend on the risk you want to take, the time you need for the study and the money that you have to spend.
In Boonchai's example there's a limit in the clinical capacity. His expected sample size is 80 and he has only the option to start with 40. What do you think about a replicate design study? A replicate design study with 40 subjects will be better than a two way cross-over study with 80 subjects devided into two groups since you can claim the widened acceptance range for Cmax.
Kind regards
Dan
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Kind regards and have a nice day
Dr_Dan
Kind regards and have a nice day
Dr_Dan
Complete thread:
- large sample size boonchai_l 2010-03-11 08:04
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- two groups (logistics) Helmut 2010-03-11 12:36
- logistical limitations = opportunities? ElMaestro 2010-03-11 21:09
- logistical limitations = opportunities? Dr_Dan 2010-03-12 09:04
- Sequential design = opportunity (IMHO) Helmut 2010-03-12 12:21
- Sequential design = opportunity (IMHO)Dr_Dan 2010-03-12 13:04
- Tasseography Helmut 2010-03-12 15:01
- sequential replicate design Dr_Dan 2010-03-15 11:21
- sequential replicate design (reference?) Helmut 2010-03-15 15:37
- sequential replicate design Dr_Dan 2010-03-15 11:21
- Tasseography Helmut 2010-03-12 15:01
- Sequential design = opportunity (IMHO)Dr_Dan 2010-03-12 13:04
- Sequential design = opportunity (IMHO) Helmut 2010-03-12 12:21
- logistical limitations = opportunities? Dr_Dan 2010-03-12 09:04
- two groups (logistics) boonchai_l 2010-03-16 12:25
- two groups (logistics) ElMaestro 2010-03-18 18:21
- logistical limitations = opportunities? ElMaestro 2010-03-11 21:09
- two groups (logistics) Helmut 2010-03-11 12:36
Ing. Helmut Schütz