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Dear all
If the drug has a great food effect and a high within-subject variability in fed conditions but not under fasting conditions I would suggest to do two studies:
Fasting: two way cross-over study
Fed: replicate study
Advantage: For the fasted study you will need less subjects and you will have less drop-outs
Kind regards
Dan
If the drug has a great food effect and a high within-subject variability in fed conditions but not under fasting conditions I would suggest to do two studies:
Fasting: two way cross-over study
Fed: replicate study
Advantage: For the fasted study you will need less subjects and you will have less drop-outs
Kind regards
Dan
—
Kind regards and have a nice day
Dr_Dan
Kind regards and have a nice day
Dr_Dan
Complete thread:
- 4-period BE study fed/fasting: statistical issues Amandine 2009-06-04 12:31
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Confounded effects; common variance Helmut 2009-06-04 12:55
- Neglecting period effects? d_labes 2009-06-10 10:10
- Assumptions... Helmut 2009-06-23 14:38
- What if... Ohlbe 2010-03-10 14:27
- What if...Dr_Dan 2010-03-11 15:50
- What if… Helmut 2010-03-11 16:39
- What if… Dr_Dan 2010-03-12 08:49
- Need-to-know / nice-to-know Helmut 2010-03-12 11:35
- many ANOVA but only one trial boonchai_l 2010-05-24 11:53
- many ANOVA but only one trial GSTATS 2010-06-08 21:52
- many ANOVA but only one trial boonchai_l 2010-05-24 11:53
- Need-to-know / nice-to-know Helmut 2010-03-12 11:35
- What if… Dr_Dan 2010-03-12 08:49
- What if… Helmut 2010-03-11 16:39
- What if...Dr_Dan 2010-03-11 15:50
- Neglecting period effects? d_labes 2009-06-10 10:10
- Confounded effects; common variance Helmut 2009-06-04 12:55
Ing. Helmut Schütz