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Dear Helmut,
I would like to calculate intra and inter CV values of PK parameters in SAS proc mixed (a bioav. study: 2 period, 2 treatments crossover design).
I found some documents about the proc mixed, but it was not enough for me to know what is the right way to get (right) results for CVs.
First of all, I set in the proc mixed to get residuals in a data set. Then I calculate MSE from the residuals.
Then I applied the formula: CV=100*sqrt(exp(MSE)-1), where I get a result, but I do not know it is the right method to get the real CV?
Or should I use covariance parameters (from SAS output) to get the CV?
What is the way to get inter, and intra CV?
Thank you!
Kvitamin
I would like to calculate intra and inter CV values of PK parameters in SAS proc mixed (a bioav. study: 2 period, 2 treatments crossover design).
I found some documents about the proc mixed, but it was not enough for me to know what is the right way to get (right) results for CVs.
First of all, I set in the proc mixed to get residuals in a data set. Then I calculate MSE from the residuals.
Then I applied the formula: CV=100*sqrt(exp(MSE)-1), where I get a result, but I do not know it is the right method to get the real CV?
Or should I use covariance parameters (from SAS output) to get the CV?
What is the way to get inter, and intra CV?
Thank you!
Kvitamin
Complete thread:
- Intra subject CV% and Inter subject CV% Ravi 2009-04-11 08:35
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- CV%-intra > CV%-inter Helmut 2009-04-11 13:19
- CV%-intra > CV%-inter Ravi 2009-04-14 06:01
- CV%-intra > CV%-interkvitamin 2009-10-07 11:40
- Proc MIXED CV%-intra, CV%-inter d_labes 2009-10-07 13:05
- Proc MIXED CV%-intra, CV%-inter kvitamin 2009-10-07 16:15
- MIXED up and lost in design d_labes 2009-10-07 16:48
- MIXED up and lost in design kvitamin 2009-10-08 10:50
- 2x2, inter, intra, total or what d_labes 2009-10-08 13:41
- 2x2, inter, intra, total or what kvitamin 2009-10-09 11:05
- 2x2, inter, intra, total or what d_labes 2009-10-08 13:41
- MIXED up and lost in design kvitamin 2009-10-08 10:50
- MIXED up and lost in design d_labes 2009-10-07 16:48
- Proc MIXED CV%-intra, CV%-inter kvitamin 2009-10-07 16:15
- Proc MIXED CV%-intra, CV%-inter d_labes 2009-10-07 13:05
- CV%-intra > CV%-inter Helmut 2009-04-11 13:19
Ing. Helmut Schütz