Bioequivalence and Bioavailability Forum

Balaam's design, sample size [General Sta­tis­tics]

posted by Helmut  – Vienna, Austria, 2009-09-25 17:44 (6118 d 06:04 ago) – Posting: # 4251
Views: 8,829

Dear Detlew,

❝ ❝ Don't ask me about sample size calculations - no idea...

❝ For the sample size calculation have a look into

❝ K.-W. Chen, S.-C. Chow and G. Li (1997)

Oh, thanks for the refresher!

❝ It comes out that the sample size needed for the Balaam's design is approx. twice that of a common classical 2x2 cross-over.

Do I miss something here?
For delta -5% (PE 95%), power 80% for the conventional 2×2 design Diletti et al. (1991) give sample sizes of 7 (10% CV), 19 (20%), and 39 (30%), whereas for Balaam’s design* according to Table V of Chen et al. (p 761) sample sizes are given with 20 (CV 10%), 72 (20%), and 156 (30%).

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• Balaam LN. A Two-Period Design with t² Experimental Units. Biometrics 1968;24(1):61–73. doi:10.2307/2528460.

—
Dif-tor heh smusma 🖖🏼 Довге життя Україна! 
Helmut Schütz


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Complete thread:

• Balaam's design graveendranath 2009-09-23 09:13 
  • Balaam's design Helmut 2009-09-23 12:47
    • Balaam's design, sample size d_labes 2009-09-24 16:13
      • Balaam's design graveendranath 2009-09-25 12:23
        • Balaam's design, intra-subject variances d_labes 2009-09-29 14:44
          • Balaam's design, intra-subject variances graveendranath 2009-09-30 13:59
      • Balaam's design, sample sizeHelmut 2009-09-25 15:44
        • Balaam's design, sample size doubled one more time d_labes 2009-09-28 11:58