Bioequivalence and Bioavailability Forum

Balaam's design, sample size [General Statistics]

posted by d_labes – Berlin, Germany, 2009-09-24 18:13 (6120 d 12:41 ago) – Posting: # 4244
Views: 9,222

Dear Helmut,

❝ [...] On the other hand ANVISA states Balaam's design in their guideline. Don't ask me about sample size calculations - no idea…

For the sample size calculation have a look into

K.-W. Chen, S.-C. Chow and G. Li
A Note on Sample Size Determination for Bioequivalence Studies with Higher-order Crossover Designs
J. Pharmacokinetics and Biopharmaceutics, Vol. 25, No. 6, p753-765 (1997)

It comes out that the sample size needed for the Balaam's design is approx. twice that of a common classical 2x2 cross-over.

—
Regards,

Detlew

Complete thread:

Balaam's design graveendranath 2009-09-23 09:13
- Balaam's design Helmut 2009-09-23 12:47
  - Balaam's design, sample sized_labes 2009-09-24 16:13
    - Balaam's design graveendranath 2009-09-25 12:23
      - Balaam's design, intra-subject variances d_labes 2009-09-29 14:44
        
        Balaam's design, intra-subject variances graveendranath 2009-09-30 13:59
    - Balaam's design, sample size Helmut 2009-09-25 15:44
      - Balaam's design, sample size doubled one more time d_labes 2009-09-28 11:58

Balaam's design, sample size [General Sta­tis­tics]

Complete thread:

Balaam's design, sample size [General Statistics]