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RegisterAssumptions... [General Statistics]
posted by Helmut 
– Vienna, Austria, 2009-06-23 16:38 (6201 d 14:27 ago) – Posting: # 3894
Views: 16,581
Dear D. Labes,
welcome back from Salzburg!
Well, with the proposed design one avoids confounding issues, but you are right that one must assume lacking period effects!
This may sound weird in the first place, but is regularily used in designs where a single dose phase is followed by a steady state phase in order to assess accumulation: AUCtau (MD) vs. AUCinf (SD). In my experience nobody sets up the study in such a way that in ½ of the subjects the study is started with the multiple dose phase first. Any potential period effects in such a design are ignored as well.
welcome back from Salzburg!
❝ What exactly You mean with "evaluated as a paired design"?
Well, with the proposed design one avoids confounding issues, but you are right that one must assume lacking period effects!
This may sound weird in the first place, but is regularily used in designs where a single dose phase is followed by a steady state phase in order to assess accumulation: AUCtau (MD) vs. AUCinf (SD). In my experience nobody sets up the study in such a way that in ½ of the subjects the study is started with the multiple dose phase first. Any potential period effects in such a design are ignored as well.
—
Dif-tor heh smusma 🖖🏼 Довге життя Україна!![[image]](https://static.bebac.at/pics/Blue_and_yellow_ribbon_UA.png)
Helmut Schütz
![[image]](https://static.bebac.at/img/CC by.png)
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Complete thread:
- 4-period BE study fed/fasting: statistical issues Amandine 2009-06-04 12:31
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Confounded effects; common variance Helmut 2009-06-04 12:55
- Neglecting period effects? d_labes 2009-06-10 10:10
- Assumptions...Helmut 2009-06-23 14:38
- What if... Ohlbe 2010-03-10 14:27
- What if... Dr_Dan 2010-03-11 15:50
- What if… Helmut 2010-03-11 16:39
- What if… Dr_Dan 2010-03-12 08:49
- Need-to-know / nice-to-know Helmut 2010-03-12 11:35
- many ANOVA but only one trial boonchai_l 2010-05-24 11:53
- many ANOVA but only one trial GSTATS 2010-06-08 21:52
- many ANOVA but only one trial boonchai_l 2010-05-24 11:53
- Need-to-know / nice-to-know Helmut 2010-03-12 11:35
- What if… Dr_Dan 2010-03-12 08:49
- What if… Helmut 2010-03-11 16:39
- What if... Dr_Dan 2010-03-11 15:50
- Neglecting period effects? d_labes 2009-06-10 10:10
- Confounded effects; common variance Helmut 2009-06-04 12:55
Ing. Helmut Schütz