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RegisterFinney Approach [General Statistics]
Dear DIXIT!
As far as I could understand Finney, I miss a second dose of test drug in your design. Otherwise I think it is not possible to calculate dose potency.
ANCOVA is possible of course as you can include co-variables in your model.
I already mentioned two literatures, one more could be:
Pharmaceutical Statistics, Applications and Clinical Applications by Sanford Bolton, Charles Bon.
This book describes Finney in general. But I think the already mentioned should be all what you need! In European Pharmacopoeia there are a lot of examples for parallel and cross-over, which can be used and programming can be done step by step and there is also described how to test slopes.
Regards,
Earlybird
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Edit: Full quote removed. Please see this post! [Ohlbe]
As far as I could understand Finney, I miss a second dose of test drug in your design. Otherwise I think it is not possible to calculate dose potency.
ANCOVA is possible of course as you can include co-variables in your model.
I already mentioned two literatures, one more could be:
Pharmaceutical Statistics, Applications and Clinical Applications by Sanford Bolton, Charles Bon.
This book describes Finney in general. But I think the already mentioned should be all what you need! In European Pharmacopoeia there are a lot of examples for parallel and cross-over, which can be used and programming can be done step by step and there is also described how to test slopes.
Regards,
Earlybird
--
Edit: Full quote removed. Please see this post! [Ohlbe]
Complete thread:
- Finney Approach dixit 2009-04-07 11:17
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Finney Approach earlybird 2009-04-08 08:10
- Finney Approach dixit 2009-04-10 07:56
- Finney Approachearlybird 2009-04-15 10:10
- Finney Approach dixit 2009-04-10 07:56
- Finney Approach earlybird 2009-04-08 08:10
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