Bioequivalence and Bioavailability Forum

Intra subject CV% and Inter subject CV% [General Statistics]

posted by Ravi – India, 2009-04-11 10:35 (6277 d 00:55 ago) – Posting: # 3507
Views: 40,528

Dear All,

In one of the BE crossover biostudy we performed, it was observed that CV_intra > CV_inter. Now my question is how does it affects the study analysis. Do we have to use the same apporach 80-125% for establishing BE or we have to modify/change our study design. What exactly we have do in this situation?

Kindly give ur valuable suggestions.

—
Thanks & Regards
Ravi Pandey

Complete thread:

Intra subject CV% and Inter subject CV%Ravi 2009-04-11 08:35
- CV%-intra > CV%-inter Helmut 2009-04-11 13:19
  - CV%-intra > CV%-inter Ravi 2009-04-14 06:01
  - CV%-intra > CV%-inter kvitamin 2009-10-07 11:40
    - Proc MIXED CV%-intra, CV%-inter d_labes 2009-10-07 13:05
      - Proc MIXED CV%-intra, CV%-inter kvitamin 2009-10-07 16:15
        
        MIXED up and lost in design d_labes 2009-10-07 16:48
        
        MIXED up and lost in design kvitamin 2009-10-08 10:50
        
        2x2, inter, intra, total or what d_labes 2009-10-08 13:41
        
        2x2, inter, intra, total or what kvitamin 2009-10-09 11:05

Intra subject CV% and Inter subject CV% [General Sta­tis­tics]

Complete thread:

Intra subject CV% and Inter subject CV% [General Statistics]