Bioequivalence and Bioavailability Forum

Dear shri!

❝ [...] in place of the "geometric least square mean", which is performed on the rest of the PK parameters analyses?

Not the ‘rest of the PK parameters’!

There are many different descriptive statistics that can be chosen as a measurement of the central tendency of data (e.g., arithmetic, geometric, harmonic mean, median, mode,…)
Based on assumptions of the underlying distribution, different averages are used:
AUC: geometric mean
Ae:  arithmetic mean
tmax: median
t½:   harmonic mean (although geometric mean used by some colleagues)

These distributional assumptions lead also to different statistical models if comparisons are performed:
AUC: multiplicative model (or additive on log-transformed data)
Ae:  additive model
tmax: nonparametric methods
t½:   no idea (suggestions? randomization test?)